Acute iliofemoral deep vein thrombosis (DVT) is associated with higher rates of severe chronic symptoms and complications, and in rare cases with acute limb ischemia. Early detection is a key to provide prompt treatment, including endovascular intervention, in selected patients. When iliofemoral DVT is related to external compression of the left iliac vein by the right common iliac artery is termed May-Thurner syndrome. Approximately, 20% to 50% of patients with chronic DVT will develop post-thrombotic syndrome, a collection of symptoms including lower extremity edema, skin changes, vein dilation, pain, fatigue, and ulcer formation.