High-dose melphalan followed by busulfan and fludarabine conditioning prior to allogeneic stem cell transplantation in elderly patients with active AML - a retrospective single center study.
In summary, our data suggest that sequential conditioning with melphalan followed by busulfan and fludarabine is effective and tolerable in elderly patients with active AML, allowing for 3-year OS of > 40%. At the same time, our data highlight the need to refine treatment strategies for elderly patients with active AML who receive transplants from < 10/10 matched donors, or patients with high leukemic burden.