Navigating the gap between guidelines and practical challenges in selecting first-line therapy for chronic lymphocytic leukemia.
The proposed framework emphasizes a patient-centered approach that integrates clinical, genetic, and logistical factors to guide CLL treatment decisions. By addressing real-world challenges such as patient preferences for all-oral regimens and quality-of-life considerations, this approach aims to deliver truly personalized care. Future updates to CLL treatment guidelines should prioritize models that align with the unique needs and priorities of CLL patients.
