НОВАЯ СТАТЬЯ
How we treat severe inherited antithrombin deficiency: lessons from cases homozygous for the Budapest 3 variant.
Guided by two illustrative cases with homozygous antithrombin Budapest 3, we report the spectrum and clinical management of patients suffering from this disorder. These cases, with very low antithrombin activity (<20%), and juvenile and recurrent venous thromboembolism, recapitulate numerous issues that one might encounter when treating patients with antithrombin deficiency. In addition, special clinical scenarios for which no formal evidence-based guidelines exist might be found more frequently in these patients, including heparin resistance, vena cava anomalies and obstetric complications. Expert proposals on the optimal management of these controversial areas, as well as future perspectives are also formulated.